Metal ions including calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) are essential for human health. Normally the distributions and concentrations of such metals are tightly controlled. If metal ion imbalances occur this leads to a plethora of disease states, including cardiovascular disease and neurological disorders.
The aim of our research is to understand from a molecular to a systems level, the complex mechanisms that regulate metal ion homeostasis and the role that these metal ions play in health and disease.
We use a wide range of experimental approaches, including in vitro functional and biochemical assays and state-of-the-art imaging techniques. Our work is supported by grants from the British Heart Foundation, BBSRC, Leverhulme Trust and Tenovus Scotland.