UKRI-BBSRC Grant Awarded to Samantha Pitt – High-resolution structure, function and anti-viral inhibition of the SARS-CoV-2 E protein ion channel

Dr Samantha Pitt and partners from University of Dundee (Prof Ulrich Zachariae) and Trinity College Dublin (Prof Martin Caffrey), have recently been awarded a UKRI-BBSRC grant to address problems related to COVID-19. Employing an interdisciplinary approach, the team will use structure-based drug design to accelerate the discovery of drugs to target SARS-CoV2 by enabling focused, rational approaches to design and repurposing. The project aims to i) solve high-resolution crystal-structures of CoV2E (ii) apply computational electrophysiology and in silico screens including cheminformatics/machine learning approaches to identify CoV2E inhibitors from libraries of commercially available and repurposing drugs, and (iii) perform lead validation and further development of inhibitors by electrophysiology and crystallography.